Postdoctoral Researcher in autophagy and metabolic homeostasis
The McWilliams Lab investigates the regulation of physiological autophagy, a membrane-driven lysosomal recycling mechanism essential for cellular and tissue homeostasis. Dysregulation of autophagy is strongly linked to neurodegeneration, cancer, and metabolic diseases, making it an attractive therapeutic target. How different autophagy mechanisms integrate with other homeostatic pathways to sustain cell survival and tissue function remains poorly understood.
We are seeking a talented postdoctoral researcher to identify and characterize novel regulators of autophagy and metabolic homeostasis. Building on our recent discoveries, the project will leverage state-of-the-art OMICs technologies, CRISPR screening, and advanced cell biology studies to identify and characterize adaptive homeostatic responses in novel disease models. These insights hold significant translational potential, particularly for pharmaceutical companies developing next-generation precision medicines targeting autophagy-related diseases. This is a unique opportunity to work at the interface of discovery and translational cell biology research in a well-resourced and collaborative research environment.
Candidate requirements
We are looking for a highly motivated researcher who meets the following criteria:
- PhD in cell biology, biochemistry, molecular biology, or a related field, with a strong academic track record and at least one recent first-author publication in an internationally recognized peer-reviewed journal.
- Strong background in cell biology. Extensive expertise in mammalian cell culture is essential.
- Strong skills and deep familiarity with molecular biology techniques (including vector design, genome targeting, PCR), and functional cell biology assays relevant to homeostasis and metabolism.
- Expertise in fluorescence-based microscopy and image analysis is highly desirable.
- A collegial and adaptive team player with a high degree of professional maturity, capable of both independent planning and collaborative teamwork.
- Excellent communication skills in the English language, with a capacity to present research findings clearly and coherently.
The chosen applicant is expected to reside in Finland while employed by the University of Helsinki.
Your priorities will include
- Driving project implementation and development in a collaborative research setting.
- Conducting functional cell biology and biochemical studies in mammalian cells to investigate novel metabolic and homeostatic pathways.
- Weekly one-on-one meetings with the PI, presenting weekly updates within the team.
- Discussing scientific work at internal meetings, with collaborators and at conferences.
What we offer
The position is initially available for 18 months. Trial period of six months will be applied. The monthly gross starting salary will be appr. 3700-4000 e/per month depending on the appointee’s qualifications and experience.
In addition, the University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Please read more at https://www.helsinki.fi/en/about-us/careers.
How to apply
Applications should be submitted through the University of Helsinki Recruitment System via the "Apply now" button.
Internal applicants (i.e., current employees of the University of Helsinki) submit their applications by using the Employee Login button.
Please send your application with following enclosures:
- A complete CV, including education, previous and current positions, publications with PMID specifiers and contact details for three referees.
- A motivation letter.
The closing date for applications is 15th of March 2025.
For further information on the position, please contact Associate Professor Thomas McWilliams (thomas.mcwilliams-at-helsinki.fi). Lab website: www.mcwilliamslab.eu.
Applicants of any gender, linguistic and cultural background or from members of minority groups are welcomed.
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The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master's Programme in Translational Medicine. It also offers psychotherapist education.
In addition to its teaching and research activities, the faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of multidisciplinary education in healthcare: https://www.helsinki.fi/en/faculty-of-medicine.
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