Hae nyt »

Doctoral Researcher (MSCA), Generation and optimization of oncolytic viruses for treatment of GBM

ImmunoViroTherapy Lab at the Faculty of Pharmacy, University of Helsinki, invites applications for the position of a

 

DOCTORAL RESEARCHER (Generation and optimization of armed oncolytic viruses (e.g. rADV-IL-12 variants) for treatment of GBM, DC 2 in MSCA-DN INTRABRAIN)

 

for a full-time position funded for three years. Earliest starting date is in September 2026, with the exact starting date negotiable after selection.

 

Position Description

 

Prof. Vincenzo Cerullo’s lab is seeking a PhD student to validate novel recombinant armed oncolytic virus variants as potential therapeutic agents for glioblastoma (GBM). The selected PhD candidate will obtain degree at the University of Helsinki. The PhD position consists of studies at Faculty of Pharmacy, University of Helsinki (UH, Finland) and secondments at consortium partner organisations in Italy, Spain and France. The position is funded by the Doctoral Network (DN) project “INTRABRAIN” of the Horizon-Marie Skłodowska-Curie Actions (MSCA).

 

The topics of the PhD candidate: The doctoral candidate will focus on developing and validating novel rADV-IL-12 variants as potential therapeutic agents for glioblastoma (GBM). Their work will involve generating recombinant oncolytic adenoviruses, evaluating their efficacy through in vitro and in vivo experiments, and analysing the immune response and antigenic profile of treated tumours. In addition, the candidate will contribute to scaling up the most promising viral constructs from laboratory research to production-ready systems. Through secondments they will gain expertise in intranasal delivery strategies, focused ultrasound technologies for enhancing drug delivery across the blood–brain barrier and nanomaterial integration. The candidate will also address technical challenges related to viral vector design and delivery by applying advanced (bio)nanotechnology-based solutions.

 

INTRABRAIN Project Description

 

The INTRABRAIN project is an ambitious and highly innovative research and training initiative aimed at revolutionising the treatment of glioblastoma multiforme (GBM) through next-generation cancer immunotherapy. By integrating cutting-edge nanotechnology, virotherapy and immunology, the project focuses on developing novel therapeutic strategies based on polymeric nanoparticles delivering engineered oncolytic adenoviruses encoding the immune-stimulating cytokines. This approach is designed to overcome major clinical challenges such as the blood–brain barrier and tumour-induced immunosuppression, enabling targeted, efficient and less invasive treatment via intranasal delivery. In parallel, INTRABRAIN fosters the training of a new generation of highly skilled doctoral researchers through interdisciplinary, intersectoral and international collaboration, equipping them with advanced scientific and transferable skills. Overall, the project aims not only to advance groundbreaking therapeutic solutions but also to contribute significantly to the future of personalised cancer medicine and biomedical innovation in Europe.

 

Requirements

 

  • To be a doctoral candidate (DC): You must, at the time of recruitment, be in the first four years (full-time equivalent) of your research career and have not been awarded a doctoral degree. Full-time equivalent research experience is measured from the date when you obtained the degree, which formally entitles you to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the research training is provided, irrespective of whether or not a doctorate was envisaged.
  • Mobility rule: At the time of the recruitment, you must not have resided or carried out your main activity (e.g. work and studies) in Finland for more than 12 months in the 3 years immediately prior to your recruitment. Short stays, such as holidays, are not taken into account.
  • English language: Network fellows (DCs) must demonstrate that their ability to understand and express themselves in both written and spoken English is sufficiently high for them to derive the full benefit from the network training.
  • Master level in Pharmaceutical Sciences, Biotechnology, Molecular Biology, Biomedical Engineering, Nanomedicine, Pharmacy, Pharmaceutical Chemistry and Technology, or related field, ideally with a multidisciplinary background in molecular biology, immunology and microbiology.

 

Right to pursue a doctoral degree

 

Please note that the appointee must obtain the right to pursue a doctoral degree at the Faculty of Pharmacy, University of Helsinki and approval by a suitable doctoral programme (Doctoral Programme in Drug Research - DPDR) by the end of the standard 6-month probationary period of the employment, unless having already existing study right. The research plan and other application material will be prepared together with the PhD supervisor(s) in the beginning of the employment period.

 

Salary and Benefits

 

Salary, pension and terms of employment are in accordance with the requirements from the European Commission related to the MSCA programme. The salary (monthly living allowance) is 3 639,84 € per month before taxes. Additionally, a monthly mobility allowance 546,15 € per month before taxes will be paid. If applicable, a conditional monthly family allowance of 507,69 € per month before taxes are paid.

 

The guaranteed PhD funding is for 36 months (i.e., funding from the European Commission). In addition to their individual scientific projects, all DCs will benefit from further education, including secondments to Technion Research and Development Foundation Ltd., Image Guided Therapy and CIC biomaGUNE, a variety of training modules as well as transferable skills courses and active participation in workshops and conferences.

 

Standard Finnish pension benefits and occupational health care are provided for University of Helsinki employees. Read more about the employee benefits at the University of Helsinki and why the University of Helsinki is an excellent career choice: https://www.helsinki.fi/en/about-us/careers. Please also see about relocation support: https://www.helsinki.fi/en/about-us/careers/welcome-finland-information-arriving-staff.

 

How to apply

 

Please submit your application, together with the required attachments AS A SINGLE PDF FILE (in the CV section), through the University of Helsinki Recruitment System via the button Apply now (or Employee login).

 

The application must contain the following documents AS A SINGLE PDF FILE (all provided in English language):

  • INTRABRAIN DC application form (download template here: https://www.intrabrain.eu/s/INTRABRAIN_DC_application-form_final.docx)
  • Curriculum Vitae (max 2 pages)
  • Cover letter (max 1 page): Indicate your motivation to apply for these specific DC position and your skills that are specifically adapted to the chosen topic, providing support evidence to your arguments.
  • Certificate of Master’s Degree (or equivalent) with transcript of records.
  • Proof of English proficiency
  • Contact details of 2 previous supervisors or employers who can give recommendation letters
  • List of publications, if applicable.
  • Manuscript of listed publication, if applicable.
  • Work/research experience certificates, if applicable.

 

All official certificates should be provided in their original European language or associated official English translation for non-European documents. If you are applying for a country different from your native country, an English supplement of the certificates with transcripts should also be provided.

 

Application deadline is on the 28 of May 2026 at 23:59 (Europe/Helsinki time).

 

Further information on:

 

This project is funded by the European Union (INTRABRAIN, 101227308). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Research Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.

 

The Faculty of Pharmacy at the University of Helsinki

  • provides the highest education in the field of pharmacy
  • offers undergraduate degrees in Bachelor of Science (Pharmacy), Master of Science (Pharmacy), Master of Science, and doctoral degrees (Doctor of Philosophy in Pharmacy, Doctor of Philosophy).
  • offers specialization studies in community and hospital pharmacy, and industrial pharmacy
  • is located at Viikki Campus in Helsinki and provides access to local and national research infrastructures
  • has about 200 employees, out of which about 20 are professors
  • has 900 undergraduate students and 140 doctoral researchers 
  • hosts the multidisciplinary Drug Research Program and the Doctoral Programme in Drug Research 
  • is a European and global leader in sustainable pharmacy
  • is a member of the ULLA consortium (European University Consortium for Pharmaceutical Sciences)


Why Finland and Helsinki


Finland is a member of the EU, has high-quality and inexpensive childcare, free schooling and tertiary training (also in English), excellent family benefits and healthcare, and is ranked as one of the top countries in the world for expat families. Finland also repeatedly tops the World Happiness Report. 

 


Monimuotoinen ja yhdenvertainen opiskelu- ja työkulttuuri ovat meille tärkeitä. Sen vuoksi teemme parhaamme edistääksemme inklusiivista yliopistoyhteisöä. Kannustamme kaikkia osaavia ja eritaustaisia hakijoita hakemaan tehtäviämme.
 
Tästä linkistä pääset lukemaan yliopistomme esteettömyydestä ja saavutettavuudesta.
 
TULE KANSSAMME TEKEMÄÄN TYÖTÄ MAAILMAN PARHAAKSI – YHDESSÄ!
#helsinkiunicareers

Onko sinulla helsinki.fi -käyttäjätunnukset ja voimassa oleva työsopimus, apurahatutkijan sopimus, vierailevan tutkijan tai vierailevan professorin sopimus Helsingin yliopistossa? Kirjaudu ensin tästä hakeaksesi avoimia tehtäviämme
Työntekijän kirjautuminen

Avoin työpaikka

Haku päättyy:  28.5.2026

(23.59 Eurooppa/Helsinki aika)
Yksikkö:  Farmasian tiedekunta
Alayksikkö:  Farmasian tiedekunta
Tunniste:  4938

Työtä maailman parhaaksi

Tieteen voimalla voidaan muuttaa maailmaa. Olemme yksi maailman parhaista tutkimusyliopistoista – yli 30 000 opiskelijan ja 8 000 työntekijän kansainvälinen tieteen, tutkimuksen, oppimisen ja rohkean ajattelun yhteisö.

Meidät tunnetaan monitieteisyydestä. Uskomme tieteidenvälisen tutkimuksen ja rajoja rikkovan yhteistyön voimaan löytää ratkaisuja ja luoda toivoa paremman ja kestävämmän tulevaisuuden puolesta.

Meitä yhdistävät arvomme totuus, sivistys, vapaus ja yhteisöllisyys, sekä halu tehdä merkityksellisiä töitä. 

Tule mukaan: tee työtä tulevaisuudelle – maailman parhaaksi.

Kysyttävää?

Katso ohjeet rekrytointijärjestelmän käyttöön

Hae nyt »